DLL4 Chromosome 15
Delta like canonical Notch ligand 4
Upload your DNA to see your personal genotypes for variants in DLL4.
What This Gene Does
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Canonical Notch ligands
Locus Type
gene with protein product
Location
15q15.1
Ensembl
ENSG00000128917
Associated Conditions (5)
Inborn genetic diseases
DLL4-related disorder
Adams-Oliver syndrome 6
Focal segmental glomerulosclerosis 9
Adams-Oliver syndrome
Key Variants
RS1228279248
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS146665183
Conflicting classifications of pathogenicity
Inborn genetic diseases, DLL4-related disorder, Inborn genetic diseases
Health Risk
RS199931075
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS369687487
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS370892158
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS373338394
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS374022749
Conflicting classifications of pathogenicity
Adams-Oliver syndrome 6, Inborn genetic diseases, Adams-Oliver syndrome 6
Health Risk
RS374162819
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS374530606
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS374783170
Conflicting classifications of pathogenicity
Inborn genetic diseases, DLL4-related disorder, Adams-Oliver syndrome 6
Health Risk
RS374910310
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS375688749
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
All Variants (39)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1228279248 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS146665183 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, DLL4-related disorder, Inborn genetic diseases |
| RS199931075 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS369687487 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS370892158 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS373338394 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS374022749 | Health Risk | Conflicting classifications of pathogenicity | Adams-Oliver syndrome 6, Inborn genetic diseases, Adams-Oliver syndrome 6 |
| RS374162819 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS374530606 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS374783170 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, DLL4-related disorder, Adams-Oliver syndrome 6 |
| RS374910310 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS375688749 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS534328045 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS754788022 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS762820678 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS1357715175 | Health Risk | Likely pathogenic | DLL4-related disorder, DLL4-related disorder |
| RS1373760209 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS1555393027 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS1555393172 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS1596194950 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS2140369593 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS2542541193 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS2542541573 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS2542549210 | Health Risk | Likely pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS745994390 | Health Risk | Likely pathogenic | — |
| RS1247027543 | Health Risk | Pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS1555393125 | Health Risk | Pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS1555393182 | Health Risk | Pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS1892853569 | Health Risk | Pathogenic | Adams-Oliver syndrome 6, Adams-Oliver syndrome 6 |
| RS2542542566 | Health Risk | Pathogenic | — |
| RS2542548141 | Health Risk | Pathogenic | — |
| RS61750844 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome |
| RS796065344 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome |
| RS796065345 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome |
| RS796065347 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome |
| RS796065348 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, DLL4-related disorder |
| RS796065350 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome |
| RS796065351 | Health Risk | Pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome |
| RS796065346 | Health Risk | Pathogenic/Likely pathogenic | Adams-Oliver syndrome, Adams-Oliver syndrome 6, Adams-Oliver syndrome |