DKK3 Chromosome 11

Dickkopf Wnt signaling pathway inhibitor 3

2 variants 2 Health Risk

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What This Gene Does

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Associated Conditions (1)

Autosomal dominant polycystic liver disease

Key Variants

RS201778105

Likely pathogenic

Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease

Health Risk

RS2134978784

Likely pathogenic

Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease

Health Risk

All Variants (2)

RSID	Category	Clinical Significance	Conditions
RS201778105	Health Risk	Likely pathogenic	Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease
RS2134978784	Health Risk	Likely pathogenic	Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease