DIS3 Chromosome 13
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
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What This Gene Does
Enables 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"Exosome complex|Endoribonucleases|PIN-like domain superfamily"
Locus Type
gene with protein product
Location
13q21.33
Ensembl
ENSG00000083520
Associated Conditions (2)
DIS3-related disorder
Multiple myeloma
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS376810829 | Health Risk | Conflicting classifications of pathogenicity | DIS3-related disorder, DIS3-related disorder |
| RS1593835248 | Health Risk | Likely pathogenic | Multiple myeloma, Multiple myeloma |