DICER1 Chromosome 14

Dicer 1, ribonuclease III

929 variants 929 Health Risk

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What This Gene Does

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]

Gene Info

Gene Group

"Endoribonucleases|MicroRNA protein coding host genes|RISC loading complex subunits"

Locus Type

gene with protein product

Location

14q32.13

Ensembl

ENSG00000100697

Associated Conditions (37)

DICER1-related tumor predisposition

Hereditary cancer-predisposing syndrome

Pleuropulmonary blastoma

Euthyroid goiter

Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome

Rhabdomyosarcoma

embryonal

Ovarian cancer

DICER1-related disorder

Breast neoplasm

Primary intracranial sarcoma

DICER1-mutant

Sertoli-Leydig cell tumor

Follicular thyroid carcinoma

Papillary thyroid carcinoma

Cancer or benign tumor

Sarcoma

Pediatric high-grade glioma

Ovarian serous cystadenocarcinoma

+17 more conditions

Key Variants

RS1024226278

Conflicting classifications of pathogenicity

Health Risk

RS1032236740

Conflicting classifications of pathogenicity

Health Risk

RS1045097916

Conflicting classifications of pathogenicity

Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome

Health Risk

RS1047347414

Conflicting classifications of pathogenicity

Health Risk

RS1060503601

Conflicting classifications of pathogenicity

Health Risk

RS1060503614

Conflicting classifications of pathogenicity

Health Risk

RS1060503616

Conflicting classifications of pathogenicity

Health Risk

RS1060503631

Conflicting classifications of pathogenicity

Health Risk

RS1060503632

Conflicting classifications of pathogenicity

Health Risk

RS1060503647

Conflicting classifications of pathogenicity

Health Risk

RS1060503649

Conflicting classifications of pathogenicity

Health Risk

RS1060503652

Conflicting classifications of pathogenicity

Health Risk

All Variants (929)

RSID	Category	Clinical Significance	Conditions
RS569346627	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS571363127	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS587778229	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS587778230	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS745802492	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS746164022	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS746668314	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Sarcoma
RS746671039	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS747021489	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS747510783	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS747901058	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Pediatric high-grade glioma
RS748079162	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS748087536	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS748847398	Health Risk	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS749810821	Health Risk	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS751764482	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
RS752116341	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Euthyroid goiter
RS752245195	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS752585711	Health Risk	Conflicting classifications of pathogenicity	DICER1-related disorder, DICER1-related disorder
RS752740048	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS752905540	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS753080447	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS753581649	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS753857234	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS754439528	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS754799308	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS755007541	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS755081246	Health Risk	Conflicting classifications of pathogenicity	Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome
RS755150419	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS755235399	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS755375348	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS755944755	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS756051157	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
RS756202530	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, DICER1-related tumor predisposition
RS756830706	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS758636143	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS759394379	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS759760077	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS759764582	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome
RS759958601	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS760384855	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS760950917	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS761971773	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS763422772	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
RS763472931	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS763583825	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS763801533	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related tumor predisposition
RS764415288	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, Euthyroid goiter
RS764747360	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder
RS766492523	Health Risk	Conflicting classifications of pathogenicity	DICER1-related tumor predisposition, Hereditary cancer-predisposing syndrome, DICER1-related disorder

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