DCAF6 Chromosome 1
DDB1 and CUL4 associated factor 6
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What This Gene Does
The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]
Gene Info
Gene Group
"WD repeat domain containing|DDB1 and CUL4 associated factors|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
1q24.2
Ensembl
ENSG00000143164
Associated Conditions (2)
Cerebral visual impairment and intellectual disability
DCAF6-related condition
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS145189179 | Health Risk | Conflicting classifications of pathogenicity | Cerebral visual impairment and intellectual disability, DCAF6-related condition, Cerebral visual impairment and intellectual disability |