C3AR1 Chromosome 12
Complement C3a receptor 1
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What This Gene Does
C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Gene Info
Gene Group
"Complement component GPCRs|Complement system regulators and receptors"
Locus Type
gene with protein product
Location
12p13.31
Ensembl
ENSG00000171860
Associated Conditions (4)
Hemolytic uremic syndrome
atypical
susceptibility to
1
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS869312973 | Health Risk | Likely pathogenic | Hemolytic uremic syndrome, atypical, susceptibility to |