BRD7 Chromosome 16
Bromodomain containing 7
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What This Gene Does
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Info
Gene Group
"Bromodomain containing|PBAF complex subunits"
Locus Type
gene with protein product
Location
16q12.1
Ensembl
ENSG00000166164
Associated Conditions (1)
Granular cell cancer
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS796065051 | Health Risk | Likely pathogenic | Granular cell cancer, Granular cell cancer |