ABCB1 Chromosome 7

ATP binding cassette subfamily B member 1

602 variants 599 Drug Response 3 Health Risk

Upload your DNA to see your personal genotypes for variants in ABCB1.

What This Gene Does

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Gene Info

Gene Group

"CD molecules|ATP binding cassette subfamily B|ATPase phospholipid transporting"

Locus Type

gene with protein product

Location

7q21.12

Ensembl

ENSG00000085563

Associated Conditions (5)

Tramadol response

Hepatocellular carcinoma

ABCB1-related disorder

Idiopathic generalized epilepsy

COLCHICINE RESISTANCE

Key Variants

RS1007307351

drug response

Tramadol response, Tramadol response

Drug Response

RS1008523470

drug response

Tramadol response, Tramadol response

Drug Response

RS1016793

drug response

Tramadol response, Tramadol response

Drug Response

RS1016975479

drug response

Tramadol response, Tramadol response

Drug Response

RS1018001117

drug response

Tramadol response, Tramadol response

Drug Response

RS1027598958

drug response

Tramadol response, Tramadol response

Drug Response

RS10276036

drug response

Tramadol response, Tramadol response

Drug Response

RS1031971223

drug response

Tramadol response, Tramadol response

Drug Response

RS1043934741

drug response

Tramadol response, Tramadol response

Drug Response

RS1046963200

drug response

Tramadol response, Tramadol response

Drug Response

RS1049335068

drug response

Tramadol response, Tramadol response

Drug Response

RS115493381

drug response

Tramadol response, Tramadol response

Drug Response

All Variants (602)

RSID	Category	Clinical Significance	Conditions
RS1007307351	Drug Response	drug response	Tramadol response, Tramadol response
RS1008523470	Drug Response	drug response	Tramadol response, Tramadol response
RS1016793	Drug Response	drug response	Tramadol response, Tramadol response
RS1016975479	Drug Response	drug response	Tramadol response, Tramadol response
RS1018001117	Drug Response	drug response	Tramadol response, Tramadol response
RS1027598958	Drug Response	drug response	Tramadol response, Tramadol response
RS10276036	Drug Response	drug response	Tramadol response, Tramadol response
RS1031971223	Drug Response	drug response	Tramadol response, Tramadol response
RS1043934741	Drug Response	drug response	Tramadol response, Tramadol response
RS1046963200	Drug Response	drug response	Tramadol response, Tramadol response
RS1049335068	Drug Response	drug response	Tramadol response, Tramadol response
RS115493381	Drug Response	drug response	Tramadol response, Tramadol response
RS116788440	Drug Response	drug response	Tramadol response, Tramadol response
RS1168879904	Drug Response	drug response	Tramadol response, Tramadol response
RS1177210906	Drug Response	drug response	Tramadol response, Tramadol response
RS1201355238	Drug Response	drug response	Tramadol response, Tramadol response
RS1202168	Drug Response	drug response	Tramadol response, Tramadol response
RS1202170	Drug Response	drug response	Tramadol response, Tramadol response
RS1209017436	Drug Response	drug response	Tramadol response, Tramadol response
RS1211152	Drug Response	drug response	Tramadol response, Tramadol response
RS1215218029	Drug Response	drug response	Tramadol response, Tramadol response
RS1222499518	Drug Response	drug response	Tramadol response, Tramadol response
RS1225969541	Drug Response	drug response	Tramadol response, Tramadol response
RS1229084791	Drug Response	drug response	Tramadol response, Tramadol response
RS1229537494	Drug Response	drug response	Tramadol response, Tramadol response
RS1235811417	Drug Response	drug response	Tramadol response, Tramadol response
RS1239586220	Drug Response	drug response	Tramadol response, Tramadol response
RS1253462004	Drug Response	drug response	Tramadol response, Tramadol response
RS1255216813	Drug Response	drug response	Tramadol response, Tramadol response
RS1259527290	Drug Response	drug response	Tramadol response, Tramadol response
RS1290687132	Drug Response	drug response	Tramadol response, Tramadol response
RS1291526534	Drug Response	drug response	Tramadol response, Tramadol response
RS1292455657	Drug Response	drug response	Tramadol response, Tramadol response
RS1297328873	Drug Response	drug response	Tramadol response, Tramadol response
RS1297599774	Drug Response	drug response	Tramadol response, Tramadol response
RS1306027704	Drug Response	drug response	Tramadol response, Tramadol response
RS1309545061	Drug Response	drug response	Tramadol response, Tramadol response
RS1317002705	Drug Response	drug response	Tramadol response, Tramadol response
RS13237132	Drug Response	drug response	Tramadol response, Tramadol response
RS1342363724	Drug Response	drug response	Tramadol response, Tramadol response
RS1347885425	Drug Response	drug response	Tramadol response, Tramadol response
RS1353756698	Drug Response	drug response	Tramadol response, Tramadol response
RS1353988860	Drug Response	drug response	Tramadol response, Tramadol response
RS1354465955	Drug Response	drug response	Tramadol response, Tramadol response
RS1368229642	Drug Response	drug response	Tramadol response, Tramadol response
RS1369339362	Drug Response	drug response	Tramadol response, Tramadol response
RS1370607856	Drug Response	drug response	Tramadol response, Tramadol response
RS1370696292	Drug Response	drug response	Tramadol response, Tramadol response
RS1372487776	Drug Response	drug response	Tramadol response, Tramadol response
RS1373455786	Drug Response	drug response	Tramadol response, Tramadol response

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