ZNRF3 Chromosome 22
Zinc and ring finger 3
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What This Gene Does
Enables frizzled binding activity and ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Ring finger proteins
Locus Type
gene with protein product
Location
22q12.1
Ensembl
ENSG00000183579
Associated Conditions (1)
ZNRF3-related disorder
Key Variants
RS2517589745
Conflicting classifications of pathogenicity
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517532919
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517585923
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517589753
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517591405
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517591470
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517591496
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
RS2517591567
Pathogenic
ZNRF3-related disorder, ZNRF3-related disorder
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2517589745 | Health Risk | Conflicting classifications of pathogenicity | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517532919 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517585923 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517589753 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517591405 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517591470 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517591496 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |
| RS2517591567 | Health Risk | Pathogenic | ZNRF3-related disorder, ZNRF3-related disorder |