ZNF335 Chromosome 20
Zinc finger protein 335
Upload your DNA to see your personal genotypes for variants in ZNF335.
What This Gene Does
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
20q13.12
Ensembl
ENSG00000198026
Associated Conditions (5)
ZNF335-related disorder
Inborn genetic diseases
Microcephalic primordial dwarfism due to ZNF335 deficiency
Aminoacylase 1 deficiency
Autism
Key Variants
RS114864530
Conflicting classifications of pathogenicity
ZNF335-related disorder, ZNF335-related disorder
Health Risk
RS117132825
Conflicting classifications of pathogenicity
ZNF335-related disorder, ZNF335-related disorder
Health Risk
RS1350201776
Conflicting classifications of pathogenicity
Inborn genetic diseases, Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases
Health Risk
RS137901051
Conflicting classifications of pathogenicity
ZNF335-related disorder, Inborn genetic diseases, ZNF335-related disorder
Health Risk
RS140528177
Conflicting classifications of pathogenicity
ZNF335-related disorder, Inborn genetic diseases, ZNF335-related disorder
Health Risk
RS141481390
Conflicting classifications of pathogenicity
Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS143113106
Conflicting classifications of pathogenicity
ZNF335-related disorder, ZNF335-related disorder
Health Risk
RS145110365
Conflicting classifications of pathogenicity
Microcephalic primordial dwarfism due to ZNF335 deficiency, ZNF335-related disorder, Microcephalic primordial dwarfism due to ZNF335 deficiency
Health Risk
RS148186790
Conflicting classifications of pathogenicity
Health Risk
RS149232277
Conflicting classifications of pathogenicity
Health Risk
RS181061162
Conflicting classifications of pathogenicity
Health Risk
RS190178539
Conflicting classifications of pathogenicity
ZNF335-related disorder, ZNF335-related disorder
Health Risk
All Variants (45)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS114864530 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS117132825 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS1350201776 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases |
| RS137901051 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, Inborn genetic diseases, ZNF335-related disorder |
| RS140528177 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, Inborn genetic diseases, ZNF335-related disorder |
| RS141481390 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases, Inborn genetic diseases |
| RS143113106 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS145110365 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, ZNF335-related disorder, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS148186790 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS149232277 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS181061162 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS190178539 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS191074858 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS200466540 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS200963656 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS201050033 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS201180565 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS35291173 | Health Risk | Conflicting classifications of pathogenicity | ZNF335-related disorder, ZNF335-related disorder |
| RS372834668 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases |
| RS539815742 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS559354455 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS564168844 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS759141702 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS759216909 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS768092083 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS768453184 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS770010402 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS772015167 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS780393773 | Health Risk | Conflicting classifications of pathogenicity | Microcephalic primordial dwarfism due to ZNF335 deficiency, Aminoacylase 1 deficiency, Autism |
| RS797046125 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1234838549 | Health Risk | Likely pathogenic | — |
| RS1334014929 | Health Risk | Likely pathogenic | — |
| RS2083680371 | Health Risk | Likely pathogenic | — |
| RS797046124 | Health Risk | Likely pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS1311197882 | Health Risk | Pathogenic | — |
| RS1362893874 | Health Risk | Pathogenic | — |
| RS1555851216 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS1568822376 | Health Risk | Pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS2083674980 | Health Risk | Pathogenic | — |
| RS2145359858 | Health Risk | Pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS2515555879 | Health Risk | Pathogenic | — |
| RS397514642 | Health Risk | Pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Inborn genetic diseases, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS749190523 | Health Risk | Pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS753888773 | Health Risk | Pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |
| RS753460205 | Health Risk | Pathogenic/Likely pathogenic | Microcephalic primordial dwarfism due to ZNF335 deficiency, Microcephalic primordial dwarfism due to ZNF335 deficiency |