ZNF292 Chromosome 6
Zinc finger protein 292
Upload your DNA to see your personal genotypes for variants in ZNF292.
What This Gene Does
This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
6q14.3
Ensembl
ENSG00000188994
Associated Conditions (14)
Neurodevelopmental disorder
Intellectual developmental disorder
autosomal dominant 64
Inborn genetic diseases
Intellectual disability
Complex neurodevelopmental disorder
ZNF292-related disorder
ZNF292-related neurodevelopmental condition
Motor delay
Autosomal dominant non-syndromic intellectual disability
Neurodevelopmental delay
Microcephaly
Mild intellectual disability
Short stature
Key Variants
RS1166797338
Conflicting classifications of pathogenicity
Neurodevelopmental disorder, Intellectual developmental disorder, autosomal dominant 64
Health Risk
RS1168689294
Conflicting classifications of pathogenicity
Health Risk
RS1215967523
Conflicting classifications of pathogenicity
Neurodevelopmental disorder, Intellectual developmental disorder, autosomal dominant 64
Health Risk
RS1256350761
Conflicting classifications of pathogenicity
Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder
Health Risk
RS1256417163
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS1774419692
Conflicting classifications of pathogenicity
Intellectual developmental disorder, autosomal dominant 64, Inborn genetic diseases
Health Risk
RS1775494843
Conflicting classifications of pathogenicity
Inborn genetic diseases, Neurodevelopmental disorder, Intellectual disability
Health Risk
RS2482298524
Conflicting classifications of pathogenicity
Complex neurodevelopmental disorder, ZNF292-related disorder, Complex neurodevelopmental disorder
Health Risk
RS369406915
Conflicting classifications of pathogenicity
Inborn genetic diseases, Intellectual developmental disorder, autosomal dominant 64
Health Risk
RS370204704
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS746371148
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS772144518
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
All Variants (91)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2482336212 | Health Risk | Likely pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482341145 | Health Risk | Likely pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482346171 | Health Risk | Likely pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482352325 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2482353118 | Health Risk | Likely pathogenic | — |
| RS2482353470 | Health Risk | Likely pathogenic | ZNF292-related disorder, ZNF292-related disorder |
| RS2482358615 | Health Risk | Likely pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS373131243 | Health Risk | Likely pathogenic | — |
| RS764995318 | Health Risk | Likely pathogenic | Neurodevelopmental disorder, Intellectual disability, ZNF292-related disorder |
| RS772762833 | Health Risk | Likely pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder |
| RS867732475 | Health Risk | Likely pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS1135401779 | Health Risk | Pathogenic | Intellectual disability, Neurodevelopmental disorder, Intellectual developmental disorder |
| RS1772907934 | Health Risk | Pathogenic | Neurodevelopmental disorder, Inborn genetic diseases, Neurodevelopmental disorder |
| RS1775285095 | Health Risk | Pathogenic | Neurodevelopmental disorder, Inborn genetic diseases, Intellectual developmental disorder |
| RS1775403177 | Health Risk | Pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder |
| RS1775468280 | Health Risk | Pathogenic | Neurodevelopmental disorder, Intellectual developmental disorder, autosomal dominant 64 |
| RS1775506324 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2127859550 | Health Risk | Pathogenic | Neurodevelopmental delay, Neurodevelopmental delay |
| RS2127863644 | Health Risk | Pathogenic | — |
| RS2127867376 | Health Risk | Pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder |
| RS2127870346 | Health Risk | Pathogenic | — |
| RS2127871916 | Health Risk | Pathogenic | — |
| RS2127872112 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2127872172 | Health Risk | Pathogenic | — |
| RS2482287354 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482290757 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482302518 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2482313661 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482321726 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2482327974 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482334414 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2482339428 | Health Risk | Pathogenic | Intellectual developmental disorder, autosomal dominant 64, Intellectual developmental disorder |
| RS2482349746 | Health Risk | Pathogenic | Inborn genetic diseases, Intellectual developmental disorder, autosomal dominant 64 |
| RS377387515 | Health Risk | Pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder |
| RS866467799 | Health Risk | Pathogenic | Neurodevelopmental disorder, Neurodevelopmental disorder |
| RS1301328139 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Intellectual disability, Intellectual developmental disorder |
| RS1775194783 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Intellectual developmental disorder, autosomal dominant 64 |
| RS1775264625 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Microcephaly, Mild intellectual disability |
| RS1775334064 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Intellectual developmental disorder, autosomal dominant 64 |
| RS1775368255 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder, Inborn genetic diseases, Neurodevelopmental disorder |
| RS865909396 | Health Risk | Pathogenic/Likely pathogenic | Intellectual disability, Neurodevelopmental disorder, Intellectual developmental disorder |