ZNF280B Chromosome 22
Zinc finger protein 280B
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What This Gene Does
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
22q11.22
Ensembl
ENSG00000275004
Associated Conditions (1)
Exstrophy-epispadias complex
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS35870543 | Health Risk | Conflicting classifications of pathogenicity | Exstrophy-epispadias complex, Exstrophy-epispadias complex |