ZNF142 Chromosome 2
Zinc finger protein 142
Upload your DNA to see your personal genotypes for variants in ZNF142.
What This Gene Does
The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Gene Info
Gene Group
Zinc fingers C2H2-type
Locus Type
gene with protein product
Location
2q35
Ensembl
ENSG00000115568
Associated Conditions (4)
Inborn genetic diseases
Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Intellectual disability
Seizure
Key Variants
RS1216015544
Conflicting classifications of pathogenicity
Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases
Health Risk
RS200699349
Conflicting classifications of pathogenicity
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS2469743343
Conflicting classifications of pathogenicity
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS756225038
Conflicting classifications of pathogenicity
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS771085529
Conflicting classifications of pathogenicity
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS1275959058
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS2106250143
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS2469638641
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS367658234
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS750239776
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
RS758344926
Likely pathogenic
Health Risk
RS776415431
Likely pathogenic
Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements
Health Risk
All Variants (26)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1216015544 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases |
| RS200699349 | Health Risk | Conflicting classifications of pathogenicity | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS2469743343 | Health Risk | Conflicting classifications of pathogenicity | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS756225038 | Health Risk | Conflicting classifications of pathogenicity | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Inborn genetic diseases, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS771085529 | Health Risk | Conflicting classifications of pathogenicity | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1275959058 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS2106250143 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS2469638641 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS367658234 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS750239776 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS758344926 | Health Risk | Likely pathogenic | — |
| RS776415431 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS989952079 | Health Risk | Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1380968057 | Health Risk | Pathogenic | — |
| RS1447313633 | Health Risk | Pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1559296368 | Health Risk | Pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1575060677 | Health Risk | Pathogenic | Intellectual disability, Seizure, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1697371244 | Health Risk | Pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS1697477844 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2469664653 | Health Risk | Pathogenic | — |
| RS2469670740 | Health Risk | Pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS369649419 | Health Risk | Pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS34864794 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS546151500 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS750681891 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |
| RS751589999 | Health Risk | Pathogenic/Likely pathogenic | Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements, Neurodevelopmental disorder with impaired speech and hyperkinetic movements |