ZMYND10 Chromosome 3
Zinc finger MYND-type containing 10
Upload your DNA to see your personal genotypes for variants in ZMYND10.
What This Gene Does
This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Gene Info
Gene Group
"Zinc fingers MYND-type|Axonemal dynein assembly factors"
Locus Type
gene with protein product
Location
3p21.31
Ensembl
ENSG00000004838
Associated Conditions (5)
Primary ciliary dyskinesia
Inborn genetic diseases
Primary ciliary dyskinesia 22
ZMYND10-related disorder
Kartagener syndrome
Key Variants
RS141261384
Conflicting classifications of pathogenicity
Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia 22
Health Risk
RS146847253
Conflicting classifications of pathogenicity
Primary ciliary dyskinesia, Primary ciliary dyskinesia 22, ZMYND10-related disorder
Health Risk
RS373018717
Conflicting classifications of pathogenicity
Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia
Health Risk
RS761674579
Conflicting classifications of pathogenicity
Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia
Health Risk
RS774583071
Conflicting classifications of pathogenicity
Primary ciliary dyskinesia, Primary ciliary dyskinesia 22, Primary ciliary dyskinesia
Health Risk
RS1195050131
Likely pathogenic
ZMYND10-related disorder, ZMYND10-related disorder
Health Risk
RS1297857806
Likely pathogenic
Primary ciliary dyskinesia, Primary ciliary dyskinesia
Health Risk
RS1298463059
Likely pathogenic
Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22
Health Risk
RS145320643
Likely pathogenic
Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22
Health Risk
RS1703436346
Likely pathogenic
Health Risk
RS1703516483
Likely pathogenic
Primary ciliary dyskinesia, Primary ciliary dyskinesia
Health Risk
RS1703516836
Likely pathogenic
Primary ciliary dyskinesia, Primary ciliary dyskinesia
Health Risk
All Variants (30)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS141261384 | Health Risk | Conflicting classifications of pathogenicity | Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia 22 |
| RS146847253 | Health Risk | Conflicting classifications of pathogenicity | Primary ciliary dyskinesia, Primary ciliary dyskinesia 22, ZMYND10-related disorder |
| RS373018717 | Health Risk | Conflicting classifications of pathogenicity | Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia |
| RS761674579 | Health Risk | Conflicting classifications of pathogenicity | Primary ciliary dyskinesia, Inborn genetic diseases, Primary ciliary dyskinesia |
| RS774583071 | Health Risk | Conflicting classifications of pathogenicity | Primary ciliary dyskinesia, Primary ciliary dyskinesia 22, Primary ciliary dyskinesia |
| RS1195050131 | Health Risk | Likely pathogenic | ZMYND10-related disorder, ZMYND10-related disorder |
| RS1297857806 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS1298463059 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS145320643 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS1703436346 | Health Risk | Likely pathogenic | — |
| RS1703516483 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS1703516836 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS2470920447 | Health Risk | Likely pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS1161101663 | Health Risk | Pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS1335327546 | Health Risk | Pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS138815960 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Kartagener syndrome, Primary ciliary dyskinesia |
| RS1703520578 | Health Risk | Pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS200913791 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia, Primary ciliary dyskinesia 22 |
| RS2109356853 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS376314608 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia, Primary ciliary dyskinesia 22 |
| RS397515460 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia, Primary ciliary dyskinesia 22 |
| RS587621539 | Health Risk | Pathogenic | Primary ciliary dyskinesia, ZMYND10-related disorder, Primary ciliary dyskinesia |
| RS587731307 | Health Risk | Pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS587777043 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia, ZMYND10-related disorder |
| RS587777044 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS587777045 | Health Risk | Pathogenic | Primary ciliary dyskinesia 22, Primary ciliary dyskinesia 22 |
| RS761505231 | Health Risk | Pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |
| RS1415036829 | Health Risk | Pathogenic/Likely pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia 22, Primary ciliary dyskinesia |
| RS2109356957 | Health Risk | Pathogenic/Likely pathogenic | Primary ciliary dyskinesia, ZMYND10-related disorder, Primary ciliary dyskinesia |
| RS373312648 | Health Risk | Pathogenic/Likely pathogenic | Primary ciliary dyskinesia, Primary ciliary dyskinesia |