ZFYVE19 Chromosome 15
Zinc finger FYVE-type containing 19
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What This Gene Does
Enables phosphatidylinositol-3-phosphate binding activity. Involved in midbody abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Located in centrosome; cleavage furrow; and midbody. Implicated in progressive familial intrahepatic cholestasis. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Zinc fingers FYVE-type
Locus Type
gene with protein product
Location
15q15.1
Ensembl
ENSG00000166140
Associated Conditions (4)
ZFYVE19-related disorder
Cholestasis
progressive familial intrahepatic
9
Key Variants
RS199947417
Conflicting classifications of pathogenicity
Health Risk
RS779395187
Likely pathogenic
ZFYVE19-related disorder, ZFYVE19-related disorder
Health Risk
RS1215965232
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
RS1890395046
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
RS375497733
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
RS753989803
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
RS769683740
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
RS771251472
Pathogenic
Cholestasis, progressive familial intrahepatic, 9
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS199947417 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS779395187 | Health Risk | Likely pathogenic | ZFYVE19-related disorder, ZFYVE19-related disorder |
| RS1215965232 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |
| RS1890395046 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |
| RS375497733 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |
| RS753989803 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |
| RS769683740 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |
| RS771251472 | Health Risk | Pathogenic | Cholestasis, progressive familial intrahepatic, 9 |