ZFP57 Chromosome 6
ZFP57 zinc finger protein
Upload your DNA to see your personal genotypes for variants in ZFP57.
What This Gene Does
The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]
Gene Info
Gene Group
"Zinc fingers C2H2-type|KRAB domain containing"
Locus Type
gene with protein product
Location
6p22.1
Ensembl
ENSG00000204644
Associated Conditions (11)
Diabetes mellitus
transient neonatal
1
Monogenic diabetes
Transitory neonatal diabetes mellitus
Gastric cancer
ZFP57-related disorder
Inborn genetic diseases
Thyroid cancer
nonmedullary
Lung cancer
Key Variants
RS114591600
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS142917604
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS146835830
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS184974475
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS193232883
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS200537697
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS201703858
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS371500990
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS575606060
Conflicting classifications of pathogenicity
ZFP57-related disorder, Inborn genetic diseases, ZFP57-related disorder
Health Risk
RS578187010
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS771387494
Conflicting classifications of pathogenicity
Diabetes mellitus, transient neonatal, 1
Health Risk
RS1362771214
Likely pathogenic
Health Risk
All Variants (25)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS114591600 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS142917604 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS146835830 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS184974475 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS193232883 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS200537697 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS201703858 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS371500990 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS575606060 | Health Risk | Conflicting classifications of pathogenicity | ZFP57-related disorder, Inborn genetic diseases, ZFP57-related disorder |
| RS578187010 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS771387494 | Health Risk | Conflicting classifications of pathogenicity | Diabetes mellitus, transient neonatal, 1 |
| RS1362771214 | Health Risk | Likely pathogenic | — |
| RS2127544675 | Health Risk | Likely pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS2481725889 | Health Risk | Likely pathogenic | — |
| RS762074022 | Health Risk | Likely pathogenic | ZFP57-related disorder, Diabetes mellitus, transient neonatal |
| RS2127547308 | Health Risk | Pathogenic | — |
| RS2127547350 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS606231121 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS606231122 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS606231123 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS61730328 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS748137597 | Health Risk | Pathogenic | — |
| RS77625743 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS78378398 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |
| RS79020217 | Health Risk | Pathogenic | Diabetes mellitus, transient neonatal, 1 |