WRN Chromosome 8
WRN RecQ like helicase
Upload your DNA to see your personal genotypes for variants in WRN.
What This Gene Does
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Info
Gene Group
"Exonucleases|RecQ like helicases"
Locus Type
gene with protein product
Location
8p12
Ensembl
ENSG00000165392
Associated Conditions (19)
Werner syndrome
Inborn genetic diseases
WRN-related disorder
Wiskott-Aldrich syndrome
Ovarian cancer
Colon adenocarcinoma
Colorectal cancer
Gastric cancer
Ovarian serous cystadenocarcinoma
Chronic lymphocytic leukemia/small lymphocytic lymphoma
Cervical cancer
Clear cell carcinoma of kidney
Malignant tumor of esophagus
Familial cancer of breast
Hereditary cancer
Papillary renal cell carcinoma type 1
Progressive pulmonary failure
6 conditions
Medulloblastoma
Key Variants
RS1053530158
Conflicting classifications of pathogenicity
Werner syndrome, Inborn genetic diseases, Werner syndrome
Health Risk
RS1056118121
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS111426441
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS115298665
Conflicting classifications of pathogenicity
Werner syndrome, WRN-related disorder, Werner syndrome
Health Risk
RS11574250
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS11574323
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS11574410
Conflicting classifications of pathogenicity
Werner syndrome, Wiskott-Aldrich syndrome, Werner syndrome
Health Risk
RS1163698357
Conflicting classifications of pathogenicity
Ovarian cancer, Werner syndrome, Ovarian cancer
Health Risk
RS1220777931
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS1233624462
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS1279354218
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
RS1292940121
Conflicting classifications of pathogenicity
Werner syndrome, Werner syndrome
Health Risk
All Variants (455)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1389423879 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1395775047 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1408863821 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1413656527 | Health Risk | Likely pathogenic | Werner syndrome, Chronic lymphocytic leukemia/small lymphocytic lymphoma, Werner syndrome |
| RS1415757819 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1434118877 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1455462438 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1474054365 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1554519449 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1554533006 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1563329555 | Health Risk | Likely pathogenic | — |
| RS1563331288 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1563341296 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1563351045 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1585449207 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1585483030 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1585517902 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1801528197 | Health Risk | Likely pathogenic | — |
| RS1801859348 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1802899166 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1803078013 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1803425342 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1813480415 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1813707238 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1813725009 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS1814007969 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome, Werner syndrome |
| RS1814197375 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS191078968 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130000832 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130048793 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130050166 | Health Risk | Likely pathogenic | Werner syndrome, Progressive pulmonary failure, Werner syndrome |
| RS2130095451 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130140321 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130157703 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130170949 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130178752 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130229490 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130282582 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130284894 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130306240 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130439413 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2130515044 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2487266223 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2487270254 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535880725 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535880796 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535887104 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535887383 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535887580 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |
| RS2535890221 | Health Risk | Likely pathogenic | Werner syndrome, Werner syndrome |