WNT2B Chromosome 1
Wnt family member 2B
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What This Gene Does
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Info
Gene Group
Wnt family
Locus Type
gene with protein product
Location
1p13.2
Ensembl
ENSG00000134245
Associated Conditions (6)
Diarrhea 9
Failure to thrive in infancy
Diarrhea
Impaired feeding ability
Chronic diarrhea
Failure to thrive
Key Variants
RS1652529952
Conflicting classifications of pathogenicity
Diarrhea 9, Diarrhea 9
Health Risk
RS1652593007
Conflicting classifications of pathogenicity
Diarrhea 9, Diarrhea 9
Health Risk
RS199522950
Conflicting classifications of pathogenicity
Health Risk
RS370244148
Likely pathogenic
Diarrhea 9, Failure to thrive in infancy, Diarrhea
Health Risk
RS751768052
Pathogenic
Health Risk
RS777193510
Pathogenic
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1652529952 | Health Risk | Conflicting classifications of pathogenicity | Diarrhea 9, Diarrhea 9 |
| RS1652593007 | Health Risk | Conflicting classifications of pathogenicity | Diarrhea 9, Diarrhea 9 |
| RS199522950 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS370244148 | Health Risk | Likely pathogenic | Diarrhea 9, Failure to thrive in infancy, Diarrhea |
| RS751768052 | Health Risk | Pathogenic | — |
| RS777193510 | Health Risk | Pathogenic | — |