WNT10B Chromosome 12
Wnt family member 10B
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What This Gene Does
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Wnt family
Locus Type
gene with protein product
Location
12q13.12
Ensembl
ENSG00000169884
Associated Conditions (6)
Inborn genetic diseases
Split hand-foot malformation 6
WNT10B-related disorder
Tooth agenesis
selective
8
Key Variants
RS138756345
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS146010731
Conflicting classifications of pathogenicity
Health Risk
RS151284263
Conflicting classifications of pathogenicity
Health Risk
RS1231016571
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS1565715468
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS1592252556
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS2137615131
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS2498935928
Likely pathogenic
Health Risk
RS561483849
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS776938956
Likely pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS121918349
Pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
RS1555177994
Pathogenic
Split hand-foot malformation 6, Split hand-foot malformation 6
Health Risk
All Variants (22)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138756345 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS146010731 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS151284263 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1231016571 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS1565715468 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS1592252556 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS2137615131 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS2498935928 | Health Risk | Likely pathogenic | — |
| RS561483849 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS776938956 | Health Risk | Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS121918349 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS1555177994 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS1940730516 | Health Risk | Pathogenic | — |
| RS2137611223 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS2137612860 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS2137615101 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS758375129 | Health Risk | Pathogenic | — |
| RS763548858 | Health Risk | Pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |
| RS763991433 | Health Risk | Pathogenic | Split hand-foot malformation 6, WNT10B-related disorder, Split hand-foot malformation 6 |
| RS766021478 | Health Risk | Pathogenic | Tooth agenesis, selective, 8 |
| RS779326570 | Health Risk | Pathogenic | Tooth agenesis, selective, 8 |
| RS1163162816 | Health Risk | Pathogenic/Likely pathogenic | Split hand-foot malformation 6, Split hand-foot malformation 6 |