WLS Chromosome 1
Wnt ligand secretion mediator
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What This Gene Does
Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
MicroRNA protein coding host genes
Locus Type
gene with protein product
Location
1p31.3
Ensembl
ENSG00000116729
Associated Conditions (2)
WLS syndrome
Zaki syndrome
Key Variants
RS2100377758
Likely pathogenic
WLS syndrome, Zaki syndrome, WLS syndrome
Health Risk
RS773311381
Likely pathogenic
WLS syndrome, Zaki syndrome, WLS syndrome
Health Risk
RS2100452147
Pathogenic
WLS syndrome, Zaki syndrome, WLS syndrome
Health Risk
RS985347096
Pathogenic/Likely pathogenic
WLS syndrome, Zaki syndrome, WLS syndrome
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2100377758 | Health Risk | Likely pathogenic | WLS syndrome, Zaki syndrome, WLS syndrome |
| RS773311381 | Health Risk | Likely pathogenic | WLS syndrome, Zaki syndrome, WLS syndrome |
| RS2100452147 | Health Risk | Pathogenic | WLS syndrome, Zaki syndrome, WLS syndrome |
| RS985347096 | Health Risk | Pathogenic/Likely pathogenic | WLS syndrome, Zaki syndrome, WLS syndrome |