VPS13C Chromosome 15
Vacuolar protein sorting 13 homolog C
Upload your DNA to see your personal genotypes for variants in VPS13C.
What This Gene Does
Involved in mitochondrion organization and negative regulation of type 2 mitophagy. Located in several cellular components, including late endosome; lipid droplet; and mitochondrial outer membrane. Implicated in Parkinson's disease 23. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Bridge-like lipid transfer protein family
Locus Type
gene with protein product
Location
15q22.2
Ensembl
ENSG00000129003
Associated Conditions (6)
Autosomal recessive early-onset Parkinson disease 23
Inborn genetic diseases
VPS13C-related disorder
Young-onset Parkinson disease
Gastric cancer
Parkinson disease
Key Variants
RS116507802
Conflicting classifications of pathogenicity
Health Risk
RS116803472
Conflicting classifications of pathogenicity
Health Risk
RS139665824
Conflicting classifications of pathogenicity
Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23
Health Risk
RS140060073
Conflicting classifications of pathogenicity
Health Risk
RS140338178
Conflicting classifications of pathogenicity
Health Risk
RS141890160
Conflicting classifications of pathogenicity
Health Risk
RS142341124
Conflicting classifications of pathogenicity
Health Risk
RS146072191
Conflicting classifications of pathogenicity
Inborn genetic diseases, VPS13C-related disorder, Inborn genetic diseases
Health Risk
RS201577653
Conflicting classifications of pathogenicity
Health Risk
RS370832130
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS372141774
Conflicting classifications of pathogenicity
Health Risk
RS374500860
Conflicting classifications of pathogenicity
Health Risk
All Variants (83)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2045915658 | Health Risk | Pathogenic | — |
| RS2140069494 | Health Risk | Pathogenic | — |
| RS2140234163 | Health Risk | Pathogenic | Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23 |
| RS2140329273 | Health Risk | Pathogenic | — |
| RS2541910203 | Health Risk | Pathogenic | — |
| RS2547818083 | Health Risk | Pathogenic | — |
| RS2547886688 | Health Risk | Pathogenic | — |
| RS2547891117 | Health Risk | Pathogenic | — |
| RS2547893982 | Health Risk | Pathogenic | — |
| RS2548147835 | Health Risk | Pathogenic | — |
| RS527383658 | Health Risk | Pathogenic | — |
| RS571944290 | Health Risk | Pathogenic | — |
| RS751054856 | Health Risk | Pathogenic | — |
| RS757630901 | Health Risk | Pathogenic | — |
| RS761323769 | Health Risk | Pathogenic | — |
| RS767007361 | Health Risk | Pathogenic | — |
| RS767990486 | Health Risk | Pathogenic | — |
| RS775841187 | Health Risk | Pathogenic | — |
| RS778239562 | Health Risk | Pathogenic | — |
| RS779017939 | Health Risk | Pathogenic | — |
| RS869312809 | Health Risk | Pathogenic | Autosomal recessive early-onset Parkinson disease 23, Parkinson disease, Autosomal recessive early-onset Parkinson disease 23 |
| RS869312810 | Health Risk | Pathogenic | Autosomal recessive early-onset Parkinson disease 23, Parkinson disease, Autosomal recessive early-onset Parkinson disease 23 |
| RS869312811 | Health Risk | Pathogenic | Autosomal recessive early-onset Parkinson disease 23, Parkinson disease, Autosomal recessive early-onset Parkinson disease 23 |
| RS869320761 | Health Risk | Pathogenic | Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23 |
| RS879253853 | Health Risk | Pathogenic | Parkinson disease, Parkinson disease |
| RS916946765 | Health Risk | Pathogenic | — |
| RS1315150327 | Health Risk | Pathogenic/Likely pathogenic | — |
| RS138846118 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23 |
| RS148074630 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23 |
| RS369100678 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive early-onset Parkinson disease 23, Parkinson disease, Young-onset Parkinson disease |
| RS752457309 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive early-onset Parkinson disease 23, Young-onset Parkinson disease, Autosomal recessive early-onset Parkinson disease 23 |
| RS755656180 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive early-onset Parkinson disease 23, Autosomal recessive early-onset Parkinson disease 23 |
| RS756149444 | Health Risk | Pathogenic/Likely pathogenic | — |