UNC5B Chromosome 10
Unc-5 netrin receptor B
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What This Gene Does
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Info
Gene Group
"I-set domain containing|Ig-like cell adhesion molecule family|ZU5 domain containing "
Locus Type
gene with protein product
Location
10q22.1
Ensembl
ENSG00000107731
Associated Conditions (1)
Autism spectrum disorder
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1845099509 | Health Risk | Conflicting classifications of pathogenicity | Autism spectrum disorder, Autism spectrum disorder |