UGT2B7 Chromosome 4

UDP glucuronosyltransferase family 2 member B7

127 variants 127 Drug Response

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What This Gene Does

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

Gene Info

Gene Group

UDP glucuronosyltransferases

Locus Type

gene with protein product

Location

4q13.2

Ensembl

ENSG00000171234

Associated Conditions (1)

Tramadol response

Key Variants

RS1048277645

drug response

Tramadol response, Tramadol response

Drug Response

RS1157290351

drug response

Tramadol response, Tramadol response

Drug Response

RS1198796766

drug response

Tramadol response, Tramadol response

Drug Response

RS12233719

drug response

Tramadol response, Tramadol response

Drug Response

RS1255338508

drug response

Tramadol response, Tramadol response

Drug Response

RS1259514034

drug response

Tramadol response, Tramadol response

Drug Response

RS12647681

drug response

Tramadol response, Tramadol response

Drug Response

RS12647682

drug response

Tramadol response, Tramadol response

Drug Response

RS12648462

drug response

Tramadol response, Tramadol response

Drug Response

RS1272501790

drug response

Tramadol response, Tramadol response

Drug Response

RS1291339023

drug response

Tramadol response, Tramadol response

Drug Response

RS1300063360

drug response

Tramadol response, Tramadol response

Drug Response

All Variants (127)

RSID	Category	Clinical Significance	Conditions
RS6851533	Drug Response	drug response	Tramadol response, Tramadol response
RS73823859	Drug Response	drug response	Tramadol response, Tramadol response
RS73823860	Drug Response	drug response	Tramadol response, Tramadol response
RS7438244	Drug Response	drug response	Tramadol response, Tramadol response
RS7439326	Drug Response	drug response	Tramadol response, Tramadol response
RS7439366	Drug Response	drug response	Tramadol response, Tramadol response
RS745638449	Drug Response	drug response	Tramadol response, Tramadol response
RS747704916	Drug Response	drug response	Tramadol response, Tramadol response
RS749400319	Drug Response	drug response	Tramadol response, Tramadol response
RS749742372	Drug Response	drug response	Tramadol response, Tramadol response
RS750282415	Drug Response	drug response	Tramadol response, Tramadol response
RS756286593	Drug Response	drug response	Tramadol response, Tramadol response
RS758574713	Drug Response	drug response	Tramadol response, Tramadol response
RS762365097	Drug Response	drug response	Tramadol response, Tramadol response
RS7668258	Drug Response	drug response	Tramadol response, Tramadol response
RS767454107	Drug Response	drug response	Tramadol response, Tramadol response
RS768744149	Drug Response	drug response	Tramadol response, Tramadol response
RS769286636	Drug Response	drug response	Tramadol response, Tramadol response
RS769560693	Drug Response	drug response	Tramadol response, Tramadol response
RS770251825	Drug Response	drug response	Tramadol response, Tramadol response
RS772560918	Drug Response	drug response	Tramadol response, Tramadol response
RS774185288	Drug Response	drug response	Tramadol response, Tramadol response
RS774459890	Drug Response	drug response	Tramadol response, Tramadol response
RS776991562	Drug Response	drug response	Tramadol response, Tramadol response
RS777092380	Drug Response	drug response	Tramadol response, Tramadol response
RS778509979	Drug Response	drug response	Tramadol response, Tramadol response
RS960076700	Drug Response	drug response	Tramadol response, Tramadol response

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