UBN1 Chromosome 16

Ubinuclein 1

1 variant 1 Health Risk

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What This Gene Does

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]

Gene Info

Gene Group

"Protein phosphatase 1 regulatory subunits|HIRA histone chaperone complex subunits"

Locus Type

gene with protein product

Location

16p13.3

Ensembl

ENSG00000118900

Associated Conditions (1)

Non-immune hydrops fetalis

Key Variants

RS765004815

Likely pathogenic

Non-immune hydrops fetalis, Non-immune hydrops fetalis

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS765004815	Health Risk	Likely pathogenic	Non-immune hydrops fetalis, Non-immune hydrops fetalis