TUBB8 Chromosome 10
Tubulin beta 8 class VIII
Upload your DNA to see your personal genotypes for variants in TUBB8.
What This Gene Does
The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]
Gene Info
Gene Group
Tubulin beta family
Locus Type
gene with protein product
Location
10p15.3
Ensembl
ENSG00000261456
Associated Conditions (2)
Oocyte maturation defect 2
Inherited oocyte maturation defect
Key Variants
RS572455524
Conflicting classifications of pathogenicity
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1339474843
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1554738360
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1588269791
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1588270347
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834346707
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834347552
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834349280
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834349710
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834349844
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834350042
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
RS1834351540
Likely pathogenic
Oocyte maturation defect 2, Oocyte maturation defect 2
Health Risk
All Variants (38)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS572455524 | Health Risk | Conflicting classifications of pathogenicity | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1339474843 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1554738360 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1588269791 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1588270347 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834346707 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834347552 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834349280 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834349710 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834349844 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834350042 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834351540 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834359656 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834371028 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834373127 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834375493 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834375618 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834382153 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834414619 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS199817418 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS781859520 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782262099 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782269374 | Health Risk | Likely pathogenic | Inherited oocyte maturation defect, Oocyte maturation defect 2, Inherited oocyte maturation defect |
| RS782492611 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782588770 | Health Risk | Likely pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1057520306 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1057520307 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS1834348631 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782246853 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782575307 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS782631950 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025271 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025272 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025273 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025609 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025610 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025611 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |
| RS869025612 | Health Risk | Pathogenic | Oocyte maturation defect 2, Oocyte maturation defect 2 |