TTC21A Chromosome 3
Tetratricopeptide repeat domain 21A
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What This Gene Does
Involved in flagellated sperm motility and spermatid development. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle A. Implicated in spermatogenic failure 37. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"Tetratricopeptide repeat domain containing|MicroRNA protein coding host genes|IFT-A complex"
Locus Type
gene with protein product
Location
3p22.2
Ensembl
ENSG00000168026
Associated Conditions (5)
TTC21A-related disorder
Spermatogenic failure 37
Lymphoma
Acute myeloid leukemia
Lung cancer
Key Variants
RS2039119649
Likely pathogenic
TTC21A-related disorder, TTC21A-related disorder
Health Risk
RS148431487
Pathogenic
Spermatogenic failure 37, Lymphoma, Acute myeloid leukemia
Health Risk
RS1559674534
Pathogenic
Spermatogenic failure 37, Spermatogenic failure 37
Health Risk
RS1559708295
Pathogenic
Spermatogenic failure 37, Spermatogenic failure 37
Health Risk
RS750057655
Pathogenic
Spermatogenic failure 37, Spermatogenic failure 37
Health Risk
RS780431020
Pathogenic
Spermatogenic failure 37, Spermatogenic failure 37
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2039119649 | Health Risk | Likely pathogenic | TTC21A-related disorder, TTC21A-related disorder |
| RS148431487 | Health Risk | Pathogenic | Spermatogenic failure 37, Lymphoma, Acute myeloid leukemia |
| RS1559674534 | Health Risk | Pathogenic | Spermatogenic failure 37, Spermatogenic failure 37 |
| RS1559708295 | Health Risk | Pathogenic | Spermatogenic failure 37, Spermatogenic failure 37 |
| RS750057655 | Health Risk | Pathogenic | Spermatogenic failure 37, Spermatogenic failure 37 |
| RS780431020 | Health Risk | Pathogenic | Spermatogenic failure 37, Spermatogenic failure 37 |