TRPM2 Chromosome 21
Transient receptor potential cation channel subfamily M member 2
Upload your DNA to see your personal genotypes for variants in TRPM2.
What This Gene Does
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Gene Info
Gene Group
"Transient receptor potential cation channels|Nudix hydrolase family"
Locus Type
gene with protein product
Location
21q22.3
Ensembl
ENSG00000142185
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS182004440 | Health Risk | Conflicting classifications of pathogenicity | — |