TRPA1 Chromosome 8
Transient receptor potential cation channel subfamily A member 1
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What This Gene Does
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Transient receptor potential cation channels|Ankyrin repeat domain containing"
Locus Type
gene with protein product
Location
8q21.11
Ensembl
ENSG00000104321
Associated Conditions (2)
Familial episodic pain syndrome with predominantly upper body involvement
Gastric cancer
Key Variants
RS147706025
Conflicting classifications of pathogenicity
Familial episodic pain syndrome with predominantly upper body involvement, Familial episodic pain syndrome with predominantly upper body involvement
Health Risk
RS199550426
Conflicting classifications of pathogenicity
Health Risk
RS61758118
Conflicting classifications of pathogenicity
Gastric cancer, Gastric cancer
Health Risk
RS61758122
Conflicting classifications of pathogenicity
Health Risk
RS74545891
Conflicting classifications of pathogenicity
Health Risk
RS398123010
Pathogenic
Familial episodic pain syndrome with predominantly upper body involvement, Familial episodic pain syndrome with predominantly upper body involvement
Health Risk
All Variants (6)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS147706025 | Health Risk | Conflicting classifications of pathogenicity | Familial episodic pain syndrome with predominantly upper body involvement, Familial episodic pain syndrome with predominantly upper body involvement |
| RS199550426 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS61758118 | Health Risk | Conflicting classifications of pathogenicity | Gastric cancer, Gastric cancer |
| RS61758122 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS74545891 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS398123010 | Health Risk | Pathogenic | Familial episodic pain syndrome with predominantly upper body involvement, Familial episodic pain syndrome with predominantly upper body involvement |