TRIM32 Chromosome 9
Tripartite motif containing 32
Upload your DNA to see your personal genotypes for variants in TRIM32.
What This Gene Does
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Ring finger proteins|Tripartite motif family"
Locus Type
gene with protein product
Location
9q33.1
Ensembl
ENSG00000119401
Associated Conditions (9)
Sarcotubular myopathy
Bardet-Biedl syndrome 11
Bardet-Biedl syndrome
TRIM32-related disorder
Inborn genetic diseases
Autosomal recessive limb-girdle muscular dystrophy
Myopathy
Retinal dystrophy
Limb-girdle muscular dystrophy
Key Variants
RS116058338
Conflicting classifications of pathogenicity
Sarcotubular myopathy, Bardet-Biedl syndrome 11, Sarcotubular myopathy
Health Risk
RS1184553729
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome
Health Risk
RS121434447
Conflicting classifications of pathogenicity
Sarcotubular myopathy, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11
Health Risk
RS1372713940
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome
Health Risk
RS138699534
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, TRIM32-related disorder, Inborn genetic diseases
Health Risk
RS140589523
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, Bardet-Biedl syndrome 11, Sarcotubular myopathy
Health Risk
RS141352486
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, Bardet-Biedl syndrome
Health Risk
RS141953092
Conflicting classifications of pathogenicity
Sarcotubular myopathy, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome
Health Risk
RS141965401
Conflicting classifications of pathogenicity
Sarcotubular myopathy, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome
Health Risk
RS142715198
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome
Health Risk
RS142781513
Conflicting classifications of pathogenicity
Health Risk
RS145728860
Conflicting classifications of pathogenicity
Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome
Health Risk
All Variants (94)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS116058338 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome 11, Sarcotubular myopathy |
| RS1184553729 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS121434447 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11 |
| RS1372713940 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS138699534 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Inborn genetic diseases |
| RS140589523 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome 11, Sarcotubular myopathy |
| RS141352486 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS141953092 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome |
| RS141965401 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome |
| RS142715198 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS142781513 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS145728860 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS145907585 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, Bardet-Biedl syndrome 11 |
| RS150318692 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS150477945 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS183136193 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, Bardet-Biedl syndrome 11 |
| RS199664043 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, TRIM32-related disorder |
| RS200085883 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS200244154 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome 11, Sarcotubular myopathy, Bardet-Biedl syndrome |
| RS200997003 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11 |
| RS201891227 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, Bardet-Biedl syndrome 11 |
| RS368455215 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS3747833 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome 11, Sarcotubular myopathy |
| RS3747834 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11 |
| RS3747835 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome 11, Bardet-Biedl syndrome, Sarcotubular myopathy |
| RS375442860 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS534259071 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS555217187 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, Bardet-Biedl syndrome 11 |
| RS572052810 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome 11, Sarcotubular myopathy, Bardet-Biedl syndrome |
| RS575633576 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome 11, Sarcotubular myopathy, Bardet-Biedl syndrome |
| RS746299779 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS750466433 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS753866301 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Sarcotubular myopathy, Bardet-Biedl syndrome 11 |
| RS753960738 | Health Risk | Conflicting classifications of pathogenicity | TRIM32-related disorder, Bardet-Biedl syndrome, TRIM32-related disorder |
| RS759707001 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome 11, Bardet-Biedl syndrome |
| RS760820148 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS761012752 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Sarcotubular myopathy |
| RS762905941 | Health Risk | Conflicting classifications of pathogenicity | Sarcotubular myopathy, Bardet-Biedl syndrome, Bardet-Biedl syndrome 11 |
| RS770015462 | Health Risk | Conflicting classifications of pathogenicity | TRIM32-related disorder, Bardet-Biedl syndrome, TRIM32-related disorder |
| RS776448126 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS778620127 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS780799984 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS886042410 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, TRIM32-related disorder, Bardet-Biedl syndrome |
| RS886043881 | Health Risk | Conflicting classifications of pathogenicity | Bardet-Biedl syndrome, Bardet-Biedl syndrome |
| RS1320628240 | Health Risk | Likely pathogenic | — |
| RS1554732594 | Health Risk | Likely pathogenic | — |
| RS1861030837 | Health Risk | Likely pathogenic | — |
| RS2491056549 | Health Risk | Likely pathogenic | Autosomal recessive limb-girdle muscular dystrophy, Autosomal recessive limb-girdle muscular dystrophy |
| RS2491063018 | Health Risk | Likely pathogenic | Bardet-Biedl syndrome 11, Bardet-Biedl syndrome 11 |
| RS2491067015 | Health Risk | Likely pathogenic | — |