TRDN Chromosome 6
Triadin
Upload your DNA to see your personal genotypes for variants in TRDN.
What This Gene Does
This gene encodes an integral membrane protein found in skeletal and cardiac muscle. The encoded protein plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex and is required for normal skeletal muscle strength. This protein indirectly links triads and microtubules in skeletal muscle. Mutations in this gene are associated with cardiac arrythmia syndrome and some variants in this gene may be associated with sudden cardiac death. [provided by RefSeq, May 2022]
Associated Conditions (8)
Cardiovascular phenotype
Catecholaminergic polymorphic ventricular tachycardia 1
Catecholaminergic polymorphic ventricular tachycardia 5
Catecholaminergic polymorphic ventricular tachycardia
TRDN-related disorder
Thyroid cancer
nonmedullary
1
Key Variants
RS1028703114
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype
Health Risk
RS1034356533
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS1040336692
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS1245664073
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS1259355217
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Cardiovascular phenotype
Health Risk
RS1335196025
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5
Health Risk
RS1375657667
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 5, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS1381728472
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS145032876
Conflicting classifications of pathogenicity
Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype
Health Risk
RS1452206168
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
RS1554258777
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype
Health Risk
RS1562358749
Conflicting classifications of pathogenicity
Catecholaminergic polymorphic ventricular tachycardia, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1
Health Risk
All Variants (101)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS766406818 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS768748530 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS768926663 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS769926882 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS773907258 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS774449661 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS777229118 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS778821180 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia |
| RS780537847 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, TRDN-related disorder, Cardiovascular phenotype |
| RS781510666 | Health Risk | Conflicting classifications of pathogenicity | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS919195476 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS9398723 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS952211002 | Health Risk | Conflicting classifications of pathogenicity | Cardiovascular phenotype, Cardiovascular phenotype |
| RS1060502116 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS1350873943 | Health Risk | Likely pathogenic | Cardiovascular phenotype, Cardiovascular phenotype |
| RS1778806259 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1781162727 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS2114436209 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2114537397 | Health Risk | Likely pathogenic | — |
| RS2532329401 | Health Risk | Likely pathogenic | — |
| RS2533571418 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS2534900959 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS753514580 | Health Risk | Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS753694760 | Health Risk | Likely pathogenic | TRDN-related disorder, TRDN-related disorder |
| RS1060502114 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1209337990 | Health Risk | Pathogenic | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS1290195833 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS1468290898 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1554251609 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1779402696 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS2114339116 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2114537918 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534346909 | Health Risk | Pathogenic | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS2534347019 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534401993 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534478800 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534485266 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534485518 | Health Risk | Pathogenic | Cardiovascular phenotype, Cardiovascular phenotype |
| RS2534485636 | Health Risk | Pathogenic | Cardiovascular phenotype, Cardiovascular phenotype |
| RS752256846 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Cardiovascular phenotype |
| RS762402822 | Health Risk | Pathogenic | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS774068079 | Health Risk | Pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1085307100 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS1198103383 | Health Risk | Pathogenic/Likely pathogenic | Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5 |
| RS1432170970 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS1780193710 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS2534485312 | Health Risk | Pathogenic/Likely pathogenic | TRDN-related disorder, Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS397515458 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Cardiovascular phenotype, Catecholaminergic polymorphic ventricular tachycardia 1 |
| RS545032318 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 5, Catecholaminergic polymorphic ventricular tachycardia 1, Cardiovascular phenotype |
| RS757805966 | Health Risk | Pathogenic/Likely pathogenic | Catecholaminergic polymorphic ventricular tachycardia 1, Catecholaminergic polymorphic ventricular tachycardia, Catecholaminergic polymorphic ventricular tachycardia 1 |