TRAP1 Chromosome 16
TNF receptor associated protein 1
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What This Gene Does
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Info
Gene Group
Heat shock 90kDa proteins
Locus Type
gene with protein product
Location
16p13.3
Ensembl
ENSG00000126602
Associated Conditions (4)
TRAP1-related disorder
Familial cancer of breast
HER2 positive breast carcinoma
Congenital anomalies of kidney and urinary tract 1
Key Variants
RS138615105
Conflicting classifications of pathogenicity
TRAP1-related disorder, TRAP1-related disorder
Health Risk
RS140670575
Conflicting classifications of pathogenicity
Health Risk
RS183666083
Conflicting classifications of pathogenicity
Health Risk
RS373016534
Conflicting classifications of pathogenicity
Familial cancer of breast, Familial cancer of breast
Health Risk
RS61756352
Conflicting classifications of pathogenicity
HER2 positive breast carcinoma, TRAP1-related disorder, HER2 positive breast carcinoma
Health Risk
RS767379047
Conflicting classifications of pathogenicity
Health Risk
RS774864487
Conflicting classifications of pathogenicity
TRAP1-related disorder, TRAP1-related disorder
Health Risk
RS2548299083
Pathogenic
Congenital anomalies of kidney and urinary tract 1, Congenital anomalies of kidney and urinary tract 1
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138615105 | Health Risk | Conflicting classifications of pathogenicity | TRAP1-related disorder, TRAP1-related disorder |
| RS140670575 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS183666083 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS373016534 | Health Risk | Conflicting classifications of pathogenicity | Familial cancer of breast, Familial cancer of breast |
| RS61756352 | Health Risk | Conflicting classifications of pathogenicity | HER2 positive breast carcinoma, TRAP1-related disorder, HER2 positive breast carcinoma |
| RS767379047 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS774864487 | Health Risk | Conflicting classifications of pathogenicity | TRAP1-related disorder, TRAP1-related disorder |
| RS2548299083 | Health Risk | Pathogenic | Congenital anomalies of kidney and urinary tract 1, Congenital anomalies of kidney and urinary tract 1 |