TNS2 Chromosome 12
Tensin 2
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What This Gene Does
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"SH2 domain containing|C2 tensin-type domain containing|PTEN protein phosphatases|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
12q13.13
Ensembl
ENSG00000111077
Associated Conditions (8)
Thyroid cancer
nonmedullary
1
Nonpapillary renal cell carcinoma
Familial cancer of breast
Cervical cancer
Colon adenocarcinoma
TNS2-related disorder
Key Variants
RS113829803
Conflicting classifications of pathogenicity
Thyroid cancer, nonmedullary, 1
Health Risk
RS114172228
Conflicting classifications of pathogenicity
Colon adenocarcinoma, Colon adenocarcinoma
Health Risk
RS117152710
Conflicting classifications of pathogenicity
TNS2-related disorder, TNS2-related disorder
Health Risk
RS138893925
Conflicting classifications of pathogenicity
Health Risk
RS139273379
Conflicting classifications of pathogenicity
Health Risk
RS139881378
Conflicting classifications of pathogenicity
TNS2-related disorder, TNS2-related disorder
Health Risk
RS143336823
Conflicting classifications of pathogenicity
Health Risk
RS201912170
Conflicting classifications of pathogenicity
Health Risk
RS537801235
Conflicting classifications of pathogenicity
TNS2-related disorder, TNS2-related disorder
Health Risk
RS540051071
Conflicting classifications of pathogenicity
TNS2-related disorder, TNS2-related disorder
Health Risk
All Variants (10)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS113829803 | Health Risk | Conflicting classifications of pathogenicity | Thyroid cancer, nonmedullary, 1 |
| RS114172228 | Health Risk | Conflicting classifications of pathogenicity | Colon adenocarcinoma, Colon adenocarcinoma |
| RS117152710 | Health Risk | Conflicting classifications of pathogenicity | TNS2-related disorder, TNS2-related disorder |
| RS138893925 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS139273379 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS139881378 | Health Risk | Conflicting classifications of pathogenicity | TNS2-related disorder, TNS2-related disorder |
| RS143336823 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201912170 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS537801235 | Health Risk | Conflicting classifications of pathogenicity | TNS2-related disorder, TNS2-related disorder |
| RS540051071 | Health Risk | Conflicting classifications of pathogenicity | TNS2-related disorder, TNS2-related disorder |