TNKS2 Chromosome 10
Tankyrase 2
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What This Gene Does
Enables NAD+ poly-ADP-ribosyltransferase activity; NAD+-protein mono-ADP-ribosyltransferase activity; and enzyme binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"Ankyrin repeat domain containing|Poly(ADP-ribose) polymerases|Sterile alpha motif domain containing"
Locus Type
gene with protein product
Location
10q23.32
Ensembl
ENSG00000107854
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS747900399 | Health Risk | Conflicting classifications of pathogenicity | — |