TNFSF15 Chromosome 9
TNF superfamily member 15
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What This Gene Does
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Info
Gene Group
Tumor necrosis factor superfamily
Locus Type
gene with protein product
Location
9q32
Ensembl
ENSG00000181634
Associated Conditions (3)
Leprosy
susceptibility to
1
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS10114470 | Health Risk | Uncertain risk allele | Leprosy, susceptibility to, 1 |
| RS4574921 | Health Risk | Uncertain risk allele | Leprosy, susceptibility to, 1 |