TNC Chromosome 9

Tenascin C

23 variants 23 Health Risk

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What This Gene Does

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Gene Info

Gene Group

Tenascins

Locus Type

gene with protein product

Location

9q33.1

Ensembl

ENSG00000041982

Associated Conditions (3)

Autosomal dominant nonsyndromic hearing loss 56

TNC-related disorder

Meniere disease

Key Variants

RS137933052

Conflicting classifications of pathogenicity

Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56

Health Risk

RS138049593

Conflicting classifications of pathogenicity

Health Risk

RS139580620

Conflicting classifications of pathogenicity

Health Risk

RS139800185

Conflicting classifications of pathogenicity

Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56

Health Risk

RS142544129

Conflicting classifications of pathogenicity

Health Risk

RS145315080

Conflicting classifications of pathogenicity

Health Risk

RS148675378

Conflicting classifications of pathogenicity

Health Risk

RS149986851

Conflicting classifications of pathogenicity

Meniere disease, TNC-related disorder, Meniere disease

Health Risk

RS150868783

Conflicting classifications of pathogenicity

Autosomal dominant nonsyndromic hearing loss 56, TNC-related disorder, Autosomal dominant nonsyndromic hearing loss 56

Health Risk

RS201169030

Conflicting classifications of pathogenicity

Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56

Health Risk

RS201311843

Conflicting classifications of pathogenicity

Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56

Health Risk

RS368280307

Conflicting classifications of pathogenicity

Health Risk

All Variants (23)

RSID	Category	Clinical Significance	Conditions
RS137933052	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS138049593	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS139580620	Health Risk	Conflicting classifications of pathogenicity	—
RS139800185	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS142544129	Health Risk	Conflicting classifications of pathogenicity	—
RS145315080	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS148675378	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS149986851	Health Risk	Conflicting classifications of pathogenicity	Meniere disease, TNC-related disorder, Meniere disease
RS150868783	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, TNC-related disorder, Autosomal dominant nonsyndromic hearing loss 56
RS201169030	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS201311843	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS368280307	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS373428721	Health Risk	Conflicting classifications of pathogenicity	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS377630352	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS530735519	Health Risk	Conflicting classifications of pathogenicity	—
RS542499079	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS61737739	Health Risk	Conflicting classifications of pathogenicity	TNC-related disorder, TNC-related disorder
RS762858023	Health Risk	Conflicting classifications of pathogenicity	—
RS774393174	Health Risk	Conflicting classifications of pathogenicity	—
RS1057519148	Health Risk	Likely pathogenic	—
RS151119387	Health Risk	Likely pathogenic	Autosomal dominant nonsyndromic hearing loss 56, TNC-related disorder, Autosomal dominant nonsyndromic hearing loss 56
RS1246681473	Health Risk	Pathogenic	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56
RS431905513	Health Risk	Pathogenic	Autosomal dominant nonsyndromic hearing loss 56, Autosomal dominant nonsyndromic hearing loss 56