TMPRSS9 Chromosome 19
Transmembrane serine protease 9
Upload your DNA to see your personal genotypes for variants in TMPRSS9.
What This Gene Does
The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016]
Gene Info
Gene Group
Type II transmembrane serine proteases
Locus Type
gene with protein product
Location
19p13.3
Ensembl
ENSG00000178297
Associated Conditions (1)
Global developmental delay
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS200715461 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS936561410 | Health Risk | Likely pathogenic | Global developmental delay, Global developmental delay |