TMEM59 Chromosome 1
Transmembrane protein 59
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What This Gene Does
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Associated Conditions (1)
Estrogen resistance syndrome
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS776119905 | Health Risk | risk factor | Estrogen resistance syndrome, Estrogen resistance syndrome |