THUMPD1 Chromosome 16

THUMP domain 1 NAT10 acetyltransferase adaptor
9 variants 9 Health Risk

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What This Gene Does
Enables RNA binding activity. Predicted to be involved in tRNA modification. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (3)
Neurodevelopmental disorder
Neurodevelopmental disorder with speech delay and variable ocular anomalies
Inborn genetic diseases
Key Variants
All Variants (9)
RSID Category Clinical Significance Conditions
RS778649204 Health Risk Conflicting classifications of pathogenicity Neurodevelopmental disorder, Neurodevelopmental disorder with speech delay and variable ocular anomalies, Inborn genetic diseases
RS772419789 Health Risk Likely pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder with speech delay and variable ocular anomalies, Neurodevelopmental disorder
RS1470272788 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS151261045 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS2152417708 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder with speech delay and variable ocular anomalies, Neurodevelopmental disorder
RS2152417882 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder with speech delay and variable ocular anomalies, Neurodevelopmental disorder
RS2152417926 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder
RS2152419456 Health Risk Pathogenic Neurodevelopmental disorder, Neurodevelopmental disorder with speech delay and variable ocular anomalies, Neurodevelopmental disorder
RS2549312956 Health Risk Pathogenic Neurodevelopmental disorder with speech delay and variable ocular anomalies, Neurodevelopmental disorder with speech delay and variable ocular anomalies
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