TGIF2LY Chromosome Y

TGFB induced factor homeobox 2 like Y-linked

1 variant 1 Health Risk

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What This Gene Does

This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

TALE class homeoboxes and pseudogenes

Locus Type

gene with protein product

Location

Yp11.2

Ensembl

ENSG00000176679

Associated Conditions (1)

Male infertility with azoospermia or oligozoospermia due to single gene mutation

Key Variants

RS760614599

Likely pathogenic

Male infertility with azoospermia or oligozoospermia due to single gene mutation, Male infertility with azoospermia or oligozoospermia due to single gene mutation

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS760614599	Health Risk	Likely pathogenic	Male infertility with azoospermia or oligozoospermia due to single gene mutation, Male infertility with azoospermia or oligozoospermia due to single gene mutation