TFG Chromosome 3

Trafficking from ER to golgi regulator
14 variants 14 Health Risk

Upload your DNA to see your personal genotypes for variants in TFG.

What This Gene Does
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Associated Conditions (7)
Hereditary motor and sensory neuropathy
Okinawa type
Hereditary spastic paraplegia 57
Inborn genetic diseases
TFG-related disorder
Amyotrophic Lateral Sclerosis with Sensory Neuropathy
See cases
Key Variants
RS111356679
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS145835282
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS370273888
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS374006808
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS376971794
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS543542721
Conflicting classifications of pathogenicity
Hereditary spastic paraplegia 57, Hereditary motor and sensory neuropathy, Okinawa type
Health Risk
RS759168672
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS775608477
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS778132572
Conflicting classifications of pathogenicity
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
RS764959531
Likely pathogenic
Health Risk
RS587777175
Pathogenic
Hereditary spastic paraplegia 57, Hereditary motor and sensory neuropathy, Okinawa type
Health Risk
RS989357227
Pathogenic
Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
Health Risk
All Variants (14)
RSID Category Clinical Significance Conditions
RS111356679 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS145835282 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS370273888 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS374006808 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS376971794 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS543542721 Health Risk Conflicting classifications of pathogenicity Hereditary spastic paraplegia 57, Hereditary motor and sensory neuropathy, Okinawa type
RS759168672 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS775608477 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS778132572 Health Risk Conflicting classifications of pathogenicity Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS764959531 Health Risk Likely pathogenic
RS587777175 Health Risk Pathogenic Hereditary spastic paraplegia 57, Hereditary motor and sensory neuropathy, Okinawa type
RS989357227 Health Risk Pathogenic Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS207482230 Health Risk Pathogenic/Likely pathogenic Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
RS587777789 Health Risk Pathogenic/Likely pathogenic Hereditary motor and sensory neuropathy, Okinawa type, Hereditary spastic paraplegia 57
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