TEX15 Chromosome 8
Testis expressed 15, meiosis and synapsis associated
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What This Gene Does
This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
Associated Conditions (4)
Spermatogenic failure 25
TEX15-related disorder
Non-obstructive azoospermia
Oligosynaptic infertility
Key Variants
RS117788795
Conflicting classifications of pathogenicity
Spermatogenic failure 25, TEX15-related disorder, Spermatogenic failure 25
Health Risk
RS144234582
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS145215857
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS146619272
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS146850714
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS150606321
Conflicting classifications of pathogenicity
Non-obstructive azoospermia, Non-obstructive azoospermia
Health Risk
RS199659098
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS376683373
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS550195743
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS565708396
Conflicting classifications of pathogenicity
Health Risk
RS76147771
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
RS767325029
Conflicting classifications of pathogenicity
Spermatogenic failure 25, Spermatogenic failure 25
Health Risk
All Variants (26)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS117788795 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, TEX15-related disorder, Spermatogenic failure 25 |
| RS144234582 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS145215857 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS146619272 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS146850714 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS150606321 | Health Risk | Conflicting classifications of pathogenicity | Non-obstructive azoospermia, Non-obstructive azoospermia |
| RS199659098 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS376683373 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS550195743 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS565708396 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS76147771 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS767325029 | Health Risk | Conflicting classifications of pathogenicity | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS1224137237 | Health Risk | Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS2486836794 | Health Risk | Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS752501149 | Health Risk | Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS754041709 | Health Risk | Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS1244093431 | Health Risk | Pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS1351772557 | Health Risk | Pathogenic | Non-obstructive azoospermia, Non-obstructive azoospermia |
| RS1554491783 | Health Risk | Pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS1554492164 | Health Risk | Pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS751384082 | Health Risk | Pathogenic | — |
| RS762458625 | Health Risk | Pathogenic | — |
| RS763654373 | Health Risk | Pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS864309485 | Health Risk | Pathogenic | Oligosynaptic infertility, Spermatogenic failure 25, Oligosynaptic infertility |
| RS141978088 | Health Risk | Pathogenic/Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |
| RS62000447 | Health Risk | Pathogenic/Likely pathogenic | Spermatogenic failure 25, Spermatogenic failure 25 |