TERB2 Chromosome 15

Telomere repeat binding bouquet formation protein 2

3 variants 3 Health Risk

Upload your DNA to see your personal genotypes for variants in TERB2.

What This Gene Does

Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within meiosis I; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. Implicated in spermatogenic failure 59. [provided by Alliance of Genome Resources, Jul 2025]

Associated Conditions (2)

Non-obstructive azoospermia

Spermatogenic failure 59

Key Variants

RS202094227

Likely pathogenic

Non-obstructive azoospermia, Non-obstructive azoospermia

Health Risk

RS1218912028

Pathogenic

Spermatogenic failure 59, Spermatogenic failure 59

Health Risk

RS2141244939

Pathogenic

Spermatogenic failure 59, Spermatogenic failure 59

Health Risk

All Variants (3)

RSID	Category	Clinical Significance	Conditions
RS202094227	Health Risk	Likely pathogenic	Non-obstructive azoospermia, Non-obstructive azoospermia
RS1218912028	Health Risk	Pathogenic	Spermatogenic failure 59, Spermatogenic failure 59
RS2141244939	Health Risk	Pathogenic	Spermatogenic failure 59, Spermatogenic failure 59