TENT5A Chromosome 6

Terminal nucleotidyltransferase 5A
5 variants 5 Health Risk

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What This Gene Does
Enables poly(A) RNA polymerase activity. Predicted to be involved in mRNA stabilization; positive regulation of bone mineralization; and positive regulation of osteoblast differentiation. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytoplasm. Implicated in lung non-small cell carcinoma; osteoarthritis; and osteogenesis imperfecta type 18. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Terminal nucleotidyltransferases
Locus Type
gene with protein product
Location
6q14.1
Ensembl
ENSG00000112773
Associated Conditions (4)
Esophageal atresia
Pyloric stenosis
Osteogenesis imperfecta
type 18
Key Variants
All Variants (5)
RSID Category Clinical Significance Conditions
RS774480008 Health Risk Conflicting classifications of pathogenicity
RS1311215973 Health Risk Likely pathogenic Esophageal atresia, Pyloric stenosis, Esophageal atresia
RS1187611948 Health Risk Pathogenic Osteogenesis imperfecta, type 18, Osteogenesis imperfecta
RS1554200371 Health Risk Pathogenic Osteogenesis imperfecta, type 18, Osteogenesis imperfecta
RS1554200383 Health Risk Pathogenic Osteogenesis imperfecta, type 18, Osteogenesis imperfecta
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