TECTA Chromosome 11
Tectorin alpha
Upload your DNA to see your personal genotypes for variants in TECTA.
What This Gene Does
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
Associated Conditions (17)
Autosomal dominant nonsyndromic hearing loss 12
Meniere disease
Autosomal recessive nonsyndromic hearing loss 21
Hearing impairment
TECTA-related disorder
Inborn genetic diseases
Ear malformation
Rare genetic deafness
Nonsyndromic genetic hearing loss
Hearing loss
autosomal recessive
Sensorineural hearing loss disorder
Deafness
neurosensory autosomal recessive 21
Monogenic hearing loss
Bilateral sensorineural hearing impairment
See cases
Key Variants
RS111759871
Conflicting classifications of pathogenicity
Autosomal dominant nonsyndromic hearing loss 12, Autosomal dominant nonsyndromic hearing loss 12
Health Risk
RS1159210445
Conflicting classifications of pathogenicity
Health Risk
RS1180694694
Conflicting classifications of pathogenicity
Health Risk
RS1223512271
Conflicting classifications of pathogenicity
Meniere disease, Meniere disease
Health Risk
RS1248649998
Conflicting classifications of pathogenicity
Health Risk
RS137916023
Conflicting classifications of pathogenicity
Health Risk
RS138185038
Conflicting classifications of pathogenicity
Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12
Health Risk
RS138477419
Conflicting classifications of pathogenicity
Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21
Health Risk
RS138644808
Conflicting classifications of pathogenicity
Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12
Health Risk
RS138768918
Conflicting classifications of pathogenicity
Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21, Hearing impairment
Health Risk
RS138843691
Conflicting classifications of pathogenicity
Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12, Inborn genetic diseases
Health Risk
RS139132568
Conflicting classifications of pathogenicity
Inborn genetic diseases, Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12
Health Risk
All Variants (225)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS769965398 | Health Risk | Pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Autosomal recessive nonsyndromic hearing loss 21 |
| RS777825421 | Health Risk | Pathogenic | — |
| RS867810468 | Health Risk | Pathogenic | — |
| RS966621865 | Health Risk | Pathogenic | Deafness, neurosensory autosomal recessive 21, Autosomal dominant nonsyndromic hearing loss 12 |
| RS121909059 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal dominant nonsyndromic hearing loss 12 |
| RS121909062 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Nonsyndromic genetic hearing loss, Autosomal dominant nonsyndromic hearing loss 12 |
| RS121909063 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Nonsyndromic genetic hearing loss, Autosomal dominant nonsyndromic hearing loss 12 |
| RS140236996 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Inborn genetic diseases, Rare genetic deafness |
| RS1455568421 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal dominant nonsyndromic hearing loss 12 |
| RS1565519673 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Hearing loss, autosomal recessive |
| RS1565522273 | Health Risk | Pathogenic/Likely pathogenic | Deafness, Hearing loss, autosomal recessive |
| RS1565541888 | Health Risk | Pathogenic/Likely pathogenic | Hearing loss, autosomal recessive, Autosomal recessive nonsyndromic hearing loss 21 |
| RS1946523602 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12 |
| RS2135050168 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal recessive nonsyndromic hearing loss 21, Autosomal dominant nonsyndromic hearing loss 12 |
| RS2496977483 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal dominant nonsyndromic hearing loss 12 |
| RS34851638 | Health Risk | Pathogenic/Likely pathogenic | Hearing impairment, Hearing impairment |
| RS368050948 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Hearing loss, autosomal recessive |
| RS374455045 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Autosomal recessive nonsyndromic hearing loss 21 |
| RS754681578 | Health Risk | Pathogenic/Likely pathogenic | — |
| RS760574657 | Health Risk | Pathogenic/Likely pathogenic | Rare genetic deafness, Rare genetic deafness |
| RS764424917 | Health Risk | Pathogenic/Likely pathogenic | Rare genetic deafness, Rare genetic deafness |
| RS764994708 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Autosomal recessive nonsyndromic hearing loss 21 |
| RS773573968 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 21, Hearing loss, autosomal recessive |
| RS878853224 | Health Risk | Pathogenic/Likely pathogenic | Autosomal dominant nonsyndromic hearing loss 12, Autosomal dominant nonsyndromic hearing loss 12 |
| RS955468054 | Health Risk | Pathogenic/Likely pathogenic | — |