SUN5 Chromosome 20

Sad1 and UNC84 domain containing 5
6 variants 6 Health Risk

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What This Gene Does
The protein encoded by this gene appears to play a role in the meiotic stage of spermatogenesis. The encoded protein localizes to the junction between the sperm head and body and may be involved in nuclear envelope reconstitution and nuclear migration. Mutations in this gene have been implicated in acephalic spermatozoa syndrome. [provided by RefSeq, May 2017]
Gene Info
Gene Group
SUN family
Locus Type
gene with protein product
Location
20q11.21
Ensembl
ENSG00000167098
Associated Conditions (1)
Spermatogenic failure 16
Key Variants
All Variants (6)
RSID Category Clinical Significance Conditions
RS754130052 Health Risk Likely pathogenic Spermatogenic failure 16, Spermatogenic failure 16
RS756459525 Health Risk Pathogenic Spermatogenic failure 16, Spermatogenic failure 16
RS886041023 Health Risk Pathogenic Spermatogenic failure 16, Spermatogenic failure 16
RS886041024 Health Risk Pathogenic Spermatogenic failure 16, Spermatogenic failure 16
RS886041025 Health Risk Pathogenic Spermatogenic failure 16, Spermatogenic failure 16
RS781693813 Health Risk Pathogenic/Likely pathogenic Spermatogenic failure 16, Spermatogenic failure 16
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