SUCO Chromosome 1
SUN domain containing ossification factor
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What This Gene Does
Predicted to be involved in positive regulation of collagen biosynthetic process; positive regulation of osteoblast differentiation; and regulation of bone remodeling. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (5)
Clear cell carcinoma of kidney
Melanoma
Acute myeloid leukemia
Malignant tumor of esophagus
Familial cancer of breast
Key Variants
RS1044499681
Conflicting classifications of pathogenicity
Health Risk
RS116494412
Conflicting classifications of pathogenicity
Health Risk
RS1236282149
Conflicting classifications of pathogenicity
Health Risk
RS145307638
Conflicting classifications of pathogenicity
Clear cell carcinoma of kidney, Melanoma, Acute myeloid leukemia
Health Risk
RS202030341
Conflicting classifications of pathogenicity
Health Risk
RS375496148
Conflicting classifications of pathogenicity
Health Risk
RS375738491
Conflicting classifications of pathogenicity
Health Risk
All Variants (7)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1044499681 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS116494412 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1236282149 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS145307638 | Health Risk | Conflicting classifications of pathogenicity | Clear cell carcinoma of kidney, Melanoma, Acute myeloid leukemia |
| RS202030341 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS375496148 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS375738491 | Health Risk | Conflicting classifications of pathogenicity | — |