SUCLG1 Chromosome 2
Succinate-CoA ligase GDP/ADP-forming subunit alpha
Upload your DNA to see your personal genotypes for variants in SUCLG1.
What This Gene Does
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Associated Conditions (4)
Mitochondrial DNA depletion syndrome 9
SUCLG1-related disorder
Inborn genetic diseases
Melanoma
Key Variants
RS113840224
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS1287269389
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS139731592
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS140626260
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS140936198
Conflicting classifications of pathogenicity
Health Risk
RS143030960
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, SUCLG1-related disorder, Mitochondrial DNA depletion syndrome 9
Health Risk
RS145106503
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS2468618218
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS369610897
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS370790297
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, SUCLG1-related disorder, Mitochondrial DNA depletion syndrome 9
Health Risk
RS371938859
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
RS372512876
Conflicting classifications of pathogenicity
Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9
Health Risk
All Variants (45)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS113840224 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1287269389 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS139731592 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS140626260 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS140936198 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS143030960 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, SUCLG1-related disorder, Mitochondrial DNA depletion syndrome 9 |
| RS145106503 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2468618218 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS369610897 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS370790297 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, SUCLG1-related disorder, Mitochondrial DNA depletion syndrome 9 |
| RS371938859 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS372512876 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS374594774 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, SUCLG1-related disorder, Mitochondrial DNA depletion syndrome 9 |
| RS376171433 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS533146473 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Inborn genetic diseases, Mitochondrial DNA depletion syndrome 9 |
| RS763324017 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS764185628 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS773748583 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS796052053 | Health Risk | Conflicting classifications of pathogenicity | Mitochondrial DNA depletion syndrome 9, Inborn genetic diseases, Mitochondrial DNA depletion syndrome 9 |
| RS1369567672 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1478044147 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2468610727 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2468618014 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2468620294 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS750388794 | Health Risk | Likely pathogenic | Mitochondrial DNA depletion syndrome 9, Melanoma, Mitochondrial DNA depletion syndrome 9 |
| RS796052050 | Health Risk | Likely pathogenic | — |
| RS796052051 | Health Risk | Likely pathogenic | — |
| RS796052052 | Health Risk | Likely pathogenic | — |
| RS1246050542 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1308442327 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1573369925 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1573369929 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1573374828 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1672524253 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS1672907018 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2104243406 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2104245141 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS2468630662 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS267607097 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS267607098 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS267607099 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS369153479 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS570210229 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS786205871 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |
| RS797046017 | Health Risk | Pathogenic | Mitochondrial DNA depletion syndrome 9, Mitochondrial DNA depletion syndrome 9 |