SNCAIP Chromosome 5
Synuclein alpha interacting protein
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What This Gene Does
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Info
Gene Group
Ankyrin repeat domain containing
Locus Type
gene with protein product
Location
5q23.2
Ensembl
ENSG00000064692
Associated Conditions (2)
Parkinson Disease
Dominant/Recessive
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS143468222 | Health Risk | Conflicting classifications of pathogenicity | Parkinson Disease, Dominant/Recessive, Parkinson Disease |
| RS755160196 | Health Risk | Conflicting classifications of pathogenicity | Parkinson Disease, Dominant/Recessive, Parkinson Disease |