SLIT1 Chromosome 10

Slit guidance ligand 1

1 variant 1 Health Risk

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What This Gene Does

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Associated Conditions (1)

Monomelic amyotrophy

Key Variants

RS2493101808

Likely pathogenic

Monomelic amyotrophy, Monomelic amyotrophy

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS2493101808	Health Risk	Likely pathogenic	Monomelic amyotrophy, Monomelic amyotrophy