SLFN11 Chromosome 17
Schlafen family member 11
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What This Gene Does
Enables ATP hydrolysis activity and tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Schlafen family
Locus Type
gene with protein product
Location
17q12
Ensembl
ENSG00000172716
Associated Conditions (1)
Moyamoya angiopathy
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1203408796 | Health Risk | Likely pathogenic | Moyamoya angiopathy, Moyamoya angiopathy |